The Future of Safe and Scientifically Validated Solutions for Cardiometabolic Health

LP_LDL^® - Superior Patented Probiotic Strain for Cardiometabolic Health

LP_LDL^® is a naturally-occurring probiotic strain of the bacterial species Lactobacillus plantarum, originally isolated from tomatoes. Lactobacilli are common members of the human gut microbiome and have traditionally been used as probiotics.What distinguishes LP_LDL^® from other probiotic strains is its remarkable efficacy in supporting cardiometabolic health. Independent human intervention studies have shown that daily intake of LP_LDL^® has a positive impact on multiple cardiometabolic health biomarkers, including Total, LDL and HDL cholesterol, Apolipoprotein B, triglycerides and blood pressure.

LP_LDL^® has been shown in multiple Independent human intervention studies to significantly improve multiple cardiometabolic health biomarkers

Total Cholesterol

LDL Cholesterol

Apolipoprotein B

Triglycerides

Blood pressure

LP_LDL^®
Natural, Safe Solution with No Side Effects

Elevated levels of cholesterol are commonly tackled by approaches that come with multiple undesirable side effects, however LP_LDL^®

offers a scientifically backed and natural alternative to support cardiovascular health and has seen no observed side effects in multiple human intervention studies.

Best out of 4,000 strains to support cardiometabolic health

LP_LDL^® was selected in pre-clinical studies, from a collection of over 4,000 microbial candidates, using ProBiotix’s ProScreen technology platform, for its superior:

Bile salt hydrolase activity
Rate of bile salt hydrolysis
Cholesterol reduction activity
Survival and metabolic activity in high concentrations of bile salts
Manufacturing suitability.

Gut-Liver Axis - Bile Salts the Link Between Gut Microbiome and Cardiometabolic Health

Bile acids are best known for their key role in aiding digestion and lipid absorption by emulsifying dietary fats.

Bile acids are synthesised in the liver from cholesterol and are conjugated into the more soluble bile salts prior to secreting in the intestine, as required.

The bile acid pool is maintained stable throughout a homeostatic mechanism that utilises cholesterol from the blood circulation to replenish their levels as required so that they can continue their metabolic function.

Mounting evidence now recognises bile acids as signalling molecules, which through their interaction with the gut microbiome, they can regulate inflammation, insulin sensitivity, blood cholesterol, fluid homeostasis and blood pressure.

LP_LDL^® was selected for its superior ability to produce enzymes which break down bile salts due to its high Bile Salt Hydrolase (BSH) activity, which is necessary both for bacterial survival in the human intestine and for its mechanism of action in reducing serum cholesterol and blood pressure.

Mechanism of Action

LP_LDL^® is a next generation probiotic, rationally selected and optimised to harness the gut-liver axis to support cardiometabolic health. As well as reducing total and LDL cholesterol, LP_LDL^® has demonstrated reductions in blood pressure, ApoB and triglycerides whilst boosting HDL cholesterol.

LP_LDL^®’s bile salt hydrolase (BSH) enzymatic activity in the intestine, reduces bile salt reabsorption into the liver.

This leads to an increase in blood cholesterol uptake by the liver as it is required to synthesise cholesterol into new bile salts to replenish and restore the bile acid pool.

Blood cholesterol levels are reduced

LP_LDL^® – Scientifically validated in independent human intervention studies to support cardiometabolic health

Backed by multiple randomized, double-blind, placebo-controlled human intervention studies, LP_LDL^® (4×10⁹ CFU/day) demonstrates statistically and clinically significant benefits: